Researchers examined data from over 35,000 individuals with European and African ancestry, revealing 40 candidate genes associated with coronary artery calcification. Notably, eight of these genes were previously unconnected to calcification, and five were novel for coronary artery disease. Some of these genes also play roles in cholesterol metabolism and inflammation, suggesting potential therapeutic targets for heart health. Further research is needed, but this study marks progress in understanding the genetics of heart disease.