MESA (Microsurgical Epididymal Sperm Aspiration) involves delicately incising an epididymal tubule to extract fluid containing sperm. This precise technique aims to overcome sperm absence in the ejaculate. However, due to the epididymis’s abundant vessels, occasional blood cell contamination may impact sperm’s fertilization potential in IVF. Understanding these intricacies is crucial for individuals exploring fertility solutions.