Women experiencing perinatal depression exhibit an increased mortality risk, indicating a concerning health outcome. The correlation between perinatal depression and increased mortality rates highlights the serious nature of this mental health disorder. Understanding and addressing this association is imperative for healthcare professionals and policymakers to develop targeted interventions that mitigate the risk and enhance overall maternal well-being. Timely identification and management of perinatal depression are crucial components in the broader framework of women’s health, ensuring not only psychological but also physical resilience during and after pregnancy. These findings emphasize the need for comprehensive healthcare strategies to address mental health challenges in the perinatal period, promoting better outcomes for affected women.