Human skin is composed of diverse cell types that have different functions and roles in health and disease. To better understand the cellular diversity and complexity of human skin, researchers are developing a Human Skin Cell Atlas, a reference guide that maps every cell type in normal human skin. This atlas will help to reveal the origin and development of inflammatory skin diseases such as eczema and psoriasis, as well as to improve regenerative medicine and tissue engineering for skin repair. The atlas will use advanced technologies such as single-cell RNA sequencing and proteomics to analyze skin cells from different individuals, ages, and body sites.