The ethanolic extract of Murraya koenigii (L) leaves demonstrates anti-obesity and hypoglycemic effects in rats subjected to a high-fat diet. This research illuminates the potential therapeutic benefits of this plant extract in addressing obesity-related complications, offering insights into its dual impact on weight management and glucose regulation. The observed effects highlight the significance of natural compounds in modulating metabolic pathways, presenting avenues for the development of botanical-based interventions against obesity and associated metabolic disorders. These findings contribute to the ongoing exploration of alternative approaches to combat the global health challenges posed by obesity and its metabolic repercussions.